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Yeast Infection Pill Fluconazole Side Effects

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Common Fluconazole Pill Medication Side Effects

Diflucan – Fluconazole

There are a wide variety of unwanted health problems, that can result at times, for individuals who take fluconazole. Here are some of the severe, and mild, side effects that you could experience when you take this drug. Some of these side effects may be dose dependant and, could be more severe if higher doses are taken into the body.

Severe Side Effects

  • Infant mortality
  • Extreme fatigue

Diflucan Side Effects List For Healthcare Professionals

  • Diflucan is generally well tolerated.
  • In some patients, particularly those with serious underlying diseases such as AIDS and cancer, changes in renal and hematological function test results and hepatic abnormalities have been observed during treatment with fluconazole and comparative agents, but the clinical significance and relationship to treatment is uncertain.

In Patients Receiving A Single Dose For Vaginal Candidiasis

  • During comparative clinical studies conducted in the United States, 448 patients with vaginal candidiasis were treated with Diflucan, 150 mg single dose.
  • The overall incidence of side effects possibly related to Diflucan was 26%.
  • In 422 patients receiving active comparative agents, the incidence was 16%.
  • The most common treatment-related adverse events reported in the patients who received 150 mg single dose fluconazole for vaginitis were
  • dizziness , and
  • taste perversion .
  • Most of the reported side effects were mild to moderate in severity. Rarely, angioedema and anaphylactic reaction have been reported in marketing experience.
  • In Patients Receiving Multiple Doses For Other Infections

    • Nervous System:Insomnia, paresthesia, somnolence, tremor, vertigo.
    • Skin and Appendages: Acute generalized exanthematous pustulosis, drug eruption including fixed drug eruption, increased sweating, exfoliative skin disorders including Stevens-Johnson syndrome and toxic epidermal necrolysis, drug reaction with eosinophilia and systemic symptoms , alopecia.

    Fluconazole May Cause Side Effects Tell Your Doctor If Any Of These Symptoms Are Severe Or Do Not Go Away:

    • swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs
    • difficulty breathing or swallowing

    Fluconazole may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

    If you experience a serious side effect, you or your doctor may send a report to the Food and Drug Administrations MedWatch Adverse Event Reporting program online or by phone .

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    How Does This Medication Work What Will It Do For Me

    Fluconazole 150 mg capsules are an antifungal medication used to treat vaginal yeast infections caused by the yeast known as Candida. It works by stopping the growth of Candida. It usually starts to work within one day, but it may take 3 days for your symptoms to improve and up to 7 days for your symptoms to disappear.

    This medication may be available under multiple brand names and/or in several different forms. Any specific brand name of this medication may not be available in all of the forms or approved for all of the conditions discussed here. As well, some forms of this medication may not be used for all of the conditions discussed here.

    Your doctor may have suggested this medication for conditions other than those listed in these drug information articles. If you have not discussed this with your doctor or are not sure why you are taking this medication, speak to your doctor. Do not stop taking this medication without consulting your doctor.

    Do not give this medication to anyone else, even if they have the same symptoms as you do. It can be harmful for people to take this medication if their doctor has not prescribed it.

    How To Treat A Yeast Infection On Your Skin

    Can men take fluconazole for yeast infection, diflucan one men

    This article was medically reviewed by Luba Lee, FNP-BC, MS and by wikiHow staff writer, Danielle Blinka, MA, MPA. Luba Lee, FNP-BC is a board certified Family Nurse Practitioner and educator in Tennessee with over a decade of clinical experience. Luba has certifications in Pediatric Advanced Life Support , Emergency Medicine, Advanced Cardiac Life Support , Team Building, and Critical Care Nursing. She received her Master of Science in Nursing from the University of Tennessee in 2006.There are 8 references cited in this article, which can be found at the bottom of the page. This article has been viewed 136,005 times.

    Treating a yeast infection on your skin is simple, and most infections clear up after a few weeks. Yeast grows naturally in and on your body, but sometimes your system has an imbalance that leads to a yeast infection. If you get one, youll want immediate relief. While the infection is bothersome, its also highly treatable if you identify a yeast infection, address the causes, and apply topical treatments.

    Read Also: Topical Antifungal For Yeast Infection

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    Side Effects Not Requiring Immediate Medical Attention

    Some side effects of fluconazole may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

    Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

    Less common

    How To Use Fluconazole Oral

    Read the Patient Information Leaflet before you start taking fluconazole and each time you get a refill. If you have any questions, ask your doctor or pharmacist.

    In Canada, some brands of this medication are available without a prescription. Before taking over-the-counter fluconazole, read the product instructions and talk to your doctor if this is your first vaginal yeast infection, if this is your second infection within 2 months, or if you are considering treatment for a girl under 12 years old.

    Take this medication by mouth usually as a single dose, with or without food at any time of the day, or as directed by your doctor.

    The effect of this medication continues for several days. If your condition does not improve after a few days or if it worsens, or if you think you may have a serious medical problem, get medical help right away.

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    How Should I Use This Medication

    The recommended dose of fluconazole for vaginal candidiasis infections is a single 150 mg dose.

    Many things can affect the dose of a medication that a person needs, such as body weight, other medical conditions, and other medications. If your doctor has recommended a dose different from the ones listed here, do not change the way that you are taking the medication without consulting your doctor.

    It is very important that this medication be taken as suggested by your doctor or pharmacist.

    Store this medication at room temperature and keep it out of the reach of children.

    Do not dispose of medications in wastewater or in household garbage. Ask your pharmacist how to dispose of medications that are no longer needed or have expired.

    More Common Side Effects

    Fluconazole (Diflucan) – Uses, Dosing, Side Effects

    The more common side effects of fluconazole oral tablet depend on how much of the drug you need to take. These side effects can include:

    • changes in the way food tastes
    • severe rash in people with lowered immunity

    If these effects are mild, they may go away within a few days or a couple of weeks. If theyre more severe or dont go away, talk with your doctor or pharmacist.

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    Are There Any Drug Interactions I Should Be Aware Of

    While using fluconazole, the following medications should be used with caution: amphotericin B, benzodiazepines, buspirone, cimetidine, cisapride, colchicine, corticosteroids, cyclophosphamide, cyclosporine, diuretics , fentanyl, losartan, macrolide antibiotics, methadone, NSAIDs, quinidine, rifampin, sildenafil, theophylline/aminophylline, tricyclic antidepressants, sulfonylurea antidiabetic agents, vincristine/vinblastine, and warfarin.

    Be sure to tell your veterinarian about any medications that your pet is taking.

    Naturally Treating Yeast Infections Safely

    According to a research paper published in Clinical Microbiology Reviews , Candida species are quite ubiquitous organisms. Candida are most frequently present in the mouth and, live in 31% to 55% of healthy people. The species that causes approximately 70% to 80% of all Candida infections is C. albicans.

    The Chinese Journal of Obstetrics and Gynecology reports there appears to be a correlation between intestinal Candida infections and vaginal yeast infections. And, this provides a clue, as to why yeast infections in general, can reoccur.

    This study states, in 148 cases of vaginal candida infections, 33.1% of the women were infected in both the intestines and vaginal area. The recurrence rate of yeast infections, in women with simultaneous intestinal infection, was significantly higher than for women who did not have an intestinal infection. This study concluded that vaginal yeast infections are highly associated with simultaneous intestinal Candida infection.

    As research appears to indicate, systemic Candida infections can and do happen. A more systemic Candida infection may primarily get a foothold in the intestines and cause a wide array of problems. If your yeast infections keep happening, a systemic Candida problem may be why.

    Linda has since published a book detailing how to copy her success. She also includes a 12 hour yeast infection cure that can get rid of a superficial yeast infection in about 12 hours.

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    Dosage For Vaginal Candidiasis

    Adult dosage

    • Typical dosage: One 150-mg dose.

    Child dosage

    Use of this drug hasnt been approved in children younger than 18 years.

    Senior dosage

    The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This raises your risk of side effects. Your doctor may start you on a lowered dose or a different dosing schedule. This can help keep levels of this drug from building up too much in your body.

    Dosage For Nonvaginal Candidiasis

    Is Diflucan Safe During Pregnancy

    Adult dosage

    • Typical dosage: Depending on the type of infection you have, your daily dose could be between 50 mg and 400 mg.
    • Treatment length: Treatment can last up to several weeks.

    Child dosage

    • Typical dosage: Dosage depends on the weight of the child taking the drug, and the type of infection being treated.
    • Treatment length: The length of treatment depends on the infection being treated.

    Child dosage

    Use of this drug isnt recommended in infants younger than 6 months.

    Senior dosage

    The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This raises your risk of side effects. Your doctor may start you on a lowered dose or a different dosing schedule. This can help keep levels of this drug from building up too much in your body.

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    Clinical Characteristics And Yeast Species

    A total of 240 patients with SVVC were enrolled the study. The average ages of participants were 29.35 and 29.89 years old in the clotrimazole group and fluconazole group respectively . Fifty-one patients had a history of VVC episodes . Seven patients had a history of antibiotic therapy prior to the development of VVC . Three patients had a history of allergy to drugs or food or an allergic disease . No patients were infected with HIV. The demographic characteristics and vaginal fungal culture analysis of the baseline vaginal isolates from the patients are shown in Table . Of those isolates, 90.0% of cases were caused by C. albicans. Non-albicans Candida included C. glabrata , C. parapsilosis , C. inconspicua , C. tropicalis and C. Krusei .


    120 120

    Eight patients withdrew from the study after enrolment because they were not willing to continue. Three patients were eliminated from the study because of drug side effects or pregnancy. Six patients were lost to follow-up .

    Figure 1

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    Report Problems To The Food And Drug Administration

    You are encouraged to report negative side effects of prescription drugs to the FDA. Visit the FDA MedWatch website or call 1-800-FDA-1088.

    Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

    CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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    Side Effects Requiring Immediate Medical Attention

    Along with its needed effects, fluconazole may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

    Check with your doctor immediately if any of the following side effects occur while taking fluconazole:


    • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
    • light-colored stools
    • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
    • stomach pain, continuing
    • blistering, peeling, or loosening of the skin
    • chest pain or discomfort
    • lower back or side pain
    • muscle spasm or jerking of the arms and legs
    • numbness or tingling in the hands, feet, or lips
    • painful or difficult urination
    • red skin lesions, often with a purple center
    • red, irritated eyes
    • sores, ulcers, or white spots in the mouth or on the lips
    • sudden loss of consciousness
    • unusual bleeding or bruising

    Get emergency help immediately if any of the following symptoms of overdose occur while taking fluconazole:

    Symptoms of overdose

    • Fearfulness, suspiciousness, or other mental changes
    • seeing, hearing, or feeling things that are not there

    Can Fluconazole Cause Problems


    Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with fluconazole. You will find a full list in the manufacturer’s information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.

    Common fluconazole side-effects What can I do if I experience this?
    Feeling sick or being sick , stomach ache, diarrhoea Stick to simple foods and drink plenty of water
    Headache Drink plenty of water and ask your pharmacist to recommend a suitable painkiller. If the headaches continue, let your doctor know
    Skin rash Let your doctor know about this
    Changes to some blood test results Your doctor will check for these if needed

    If you experience any other symptoms which you think may be due to fluconazole, discuss them with your doctor or pharmacist for further advice.

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    Are There Any Other Precautions Or Warnings For This Medication

    Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.

    General: If this is your first yeast infection, if you have frequent yeast infections or heart disease, if you have another yeast infection within 2 months after taking this medication, or if you have multiple sexual partners or change partners often, talk to your doctor or pharmacist before taking this medication. This medication should only be taken as a single dose.

    The following symptoms are not caused by a yeast infection. Contact your doctor for treatment advice, if you experience them:

    • discharge with a foul odour
    • fever or chills
    • lower back or shoulder pain
    • nausea, vomiting, or diarrhea
    • painful urination

    If your symptoms have not improved in 3 days or disappeared in 7 days, contact your doctor.

    Grapefruit juice: Taking fluconazole at the same time as drinking grapefruit juice may cause fluconazole to build up in the body and cause side effects. Avoid drinking grapefruit juice if you are taking this medication.

    Intercourse and birth control: Vaginal intercourse should be avoided when women have a yeast infection. This will help reduce the risk of infecting your sexual partner.

    What Causes Vaginal Candidiasis

    The yeast, Candida Albicans, is the most common cause of vaginal candidiasis. Yeasts are a type of fungus.

    Factors that may cause a disruption in the balance of bacteria and yeast include:

    • Using vaginal douches or vaginal sprays
    • Wearing tight underwear and synthetic clothes that dont breathe.

    Although vaginal yeast infections are not considered a sexually transmitted infection, sexual intercourse can trigger or spread them. Women who arent sexually active can also get them. Some women are prone to yeast infections and get them relatively regularly.

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    Does Diflucan Cause Side Effects

    Diflucan is an antifungal medication used to treat vaginal, oral, and esophageal fungal infections caused by Candida.

    It is used for treating uncomplicated, complicated, or recurrent vaginal Candida infections. Diflucan also may be effective in treating urinary tract infections , peritonitis, pneumonia and disseminated infections caused by Candida.

    Diflucan is also used to treat cryptococcal meningitis, and prevention of Candida infections in patients treated with chemotherapy or radiation after bone marrow transplantation. Diflucan prevents growth of fungi by preventing production of the membranes that surround fungal cells.

    Common side effects of Diflucan include

    Rarely, serious allergic reactions, including angioedema , may also occur.

    Drug interactions of Diflucan include hydrochlorothiazide, which increases the blood concentration of Diflucan by 40%.

    • Rifampin reduces the blood concentration of oral Diflucan, probably by increasing the elimination of Diflucan in the liver therefore, reducing the effectiveness of Diflucan.
    • Diflucan may increase the concentration of warfarin in blood by reducing the elimination of warfarin.
    • Therefore, the effect of warfarin may increase, leading to an increased tendency to bleed.
    • Combining Diflucan with amiodarone, pimozide, bepridil or other drugs that affect heart rhythm may increase the risk of abnormal heart rhythms.

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