Side Effects Of Diflucan
Like all other medications, Diflucan has its share of side effects and potential adverse reactions.
However, the occurrence and severity of Diflucan side effects depend on the dosage taken.
Diflucans most common side effects are headaches, nausea, and stomach pain. Other common side effects also include:
- Numbness of the hands, feet, or lips
- Increased thirst
Some rare side effects of Diflucan point towards other more serious conditions and adverse effects.
For instance, the combination of dark urine, light-colored stools, severe itching, and vomiting may indicate liver damage.
In addition, muscle weakness, fatigue, appetite loss, and stomach pain are symptoms of adrenal gland problems.
Meanwhile, fast or irregular heart rate, dizziness, fainting, and seizures indicate torsades de pointes, a severe and potentially fatal heart rhythm condition.
Monistat Vs Diflucan: Differences Similarities And Which Is Better For You
Vaginal yeast infections are a relatively common and very treatable condition that many women face. These infections are typically caused by an overgrowth of a fungal group known as candida albicans, which is present in the normal vaginal flora of most women. When certain conditions allow the overgrowth of vaginal candida, also known as candidiasis, it leads to symptoms that may include vaginal tenderness, itching, discharge, and/or odor. The sensitivity of this condition leaves many women looking for a quick and effective treatment option. Monistat and Diflucan are two treatment options for vulvovaginal candidiasis.
Uses Of Diflucan For Infection
Diflucan is officially indicated for the treatment of the following medical conditions:
Vaginal candidiasis: Doctors recommend a 150 mg dose of Diflucan in tablet form for vaginal yeast or candida.
Oropharyngeal candidiasis: Also referred to as oral candidiasis or simply oral thrush.
Patients generally undergo Diflucan treatment for at least two weeks to lower the likelihood of a relapse.
Candidiasis of the esophagus: A fungal infection of the esophagus or throat, sometimes called esophageal thrush.
Diflucan treatment typically lasts at least three weeks, plus another two weeks minimum after symptoms stop.
Cryptococcal meningitis: Doctors generally recommend 400 mg of Diflucan on the first day and 200 mg daily for the rest of the 10 to 12 weeks of treatment.
Systemic infections of candida: Diflucan is also prescribed for other infections of candida, including pneumonia, disseminated candidiasis, which affects the liver and spleen, and candidemia, a bloodstream infection.
Urinary tract infections: Doctors may prescribe between 50 to 200 mg of Diflucan for adult patients with UTIs and peritonitis.
Diflucan is also a precaution for candidiasis in patients receiving cytotoxic chemotherapy or radiation therapy as they undergo bone marrow transplantation.
Patients with a high risk of developing a significant decrease in their granulocytes should undergo Diflucan prophylaxis at least several days before the expected onset of the condition.
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What Should I Know About Storage And Disposal Of This Medication
Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture . Dispose of any unused liquid medication after 14 days.
It is important to keep all medication out of sight and reach of children as many containers are not child-resistant and young children can open them easily. To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location â one that is up and away and out of their sight and reach.
Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. See the FDA’s Safe Disposal of Medicines website for more information if you do not have access to a take-back program.
More Common Side Effects
The more common side effects of fluconazole oral tablet depend on how much of the drug you need to take. These side effects can include:
- changes in the way food tastes
- severe rash in people with lowered immunity
If these effects are mild, they may go away within a few days or a couple of weeks. If theyre more severe or dont go away, talk with your doctor or pharmacist.
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Dose Regime For Oral Fluconazole
For vulvovaginal candidiasis, a single oral dose of fluconazole 150 mg is usually effective. It can be repeated.
Once-weekly fluconazole is often used off-label to treat toenail fungal infections .
Larger doses are required for systemic infections.
Fluconazole is not normally used in children but doses of 5 mg/kg/day have been safely prescribed for a serious infection.
Fluconazole Dosage For Vaginal Candidiasis
Vaginal candidiasis is one of the most common uses for fluconazole. In patients with uncomplicated disease , a one-day treatment is sufficient. Patients with complicated disease may require longer therapy, typically fluconazole every three days for three doses. Recurrent disease requires weekly fluconazole for six months. Finally, pregnant patients should not use oral fluconazole due to its potential for harm to the fetus. Rather, a seven-day course of intravaginal therapy should be used.
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Fluconazole Dosage For Prevention Of Candidiasis In Bmt Patients
The recommended fluconazole dosage for preventing candidiasis in patients undergoing bone marrow transplantation is 400 mg daily. In patients who are likely to have severe neutropenia , fluconazole therapy should begin several days before the onset of neutropenia and continued for one week after neutrophil count returns to 1,000 cells per cubic mm or higher.
Possible Negative Reactions Of Using Diflucan For Yeast Infection
Like many other prescription medications, Diflucan may cause potential negative reactions such as allergies.
Therefore, the drug carries an allergy warning and cautions individuals with a known hypersensitivity to fluconazole or other azoles on taking Diflucan.
In case of a severe reaction, patients are advised to immediately contact their doctor or the local poison control center.
Severe symptoms may require a trip to the emergency room.
Symptoms of an allergic reaction to Diflucan include:
- Skin rash, hives, blisters, or skin peeling
- Shortness of breath
- Fever and chills
- Swelling of the face or other body parts
Diflucan also affects people with lower or compromised immunity differently. For example, individuals with HIV, AIDS, or cancer patients undergoing chemotherapy have a higher risk of developing rashes and skin irritation from Diflucan.
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Dosage In Patients With Impaired Renal Function
Fluconazole is cleared primarily by renal excretion as unchanged drug. There is no need to adjust single dose therapy for vaginal candidiasis because of impaired renal function. In patients with impaired renal function who will receive multiple doses of DIFLUCAN, an initial loading dose of 50 mg to 400 mg should be given. After the loading dose, the daily dose should be based on the following table:
|Hemodialysis||100% after each hemodialysis|
Patients on hemodialysis should receive 100% of the recommended dose after each hemodialysis on non-dialysis days, patients should receive a reduced dose according to their creatinine clearance.
These are suggested dose adjustments based on pharmacokinetics following administration of multiple doses. Further adjustment may be needed depending upon clinical condition.
When serum creatinine is the only measure of renal function available, the following formula should be used to estimate the creatinine clearance in adults:
|72 Ã serum creatinine|
Females: 0.85 Ã above value
Although the pharmacokinetics of fluconazole has not been studied in children with renal insufficiency, dosage reduction in children with renal insufficiency should parallel that recommended for adults. The following formula may be used to estimate creatinine clearance in children:
Take Care Of Your Vaginal Health
Notice changes in your vaginal health? Some vaginal symptoms are completely normal while others may be a sign of an infection. While symptoms like vaginal itching, burning and inflammation often point to a yeast infection, they are also common with conditions like bacterial vaginosis and some sexually transmitted infections. If your symptoms dont resolve after treatment, get worse or are accompanied by other worrisome symptoms, its a good idea to be seen in person by a doctor.
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What If Fluconazole Does Not Work
Talk to your doctor if your symptoms do not improve after 7 days of taking fluconazole for vaginal thrush, balanitis or oral thrush. Your doctor may ask you to take fluconazole for longer, or they may prescribe a different antifungal treatment. If your symptoms get worse at any time, speak to your doctor.
What Are Yeast Infection Symptoms
At some point, every woman will know the discomfort of a yeast infection. Many will get to know the feeling oftena little too often. But, theres no need to suffer through chronic yeast infections if your go-to over the counter yeast infection treatment doesnt work. Antifungals are prescription strength yeast infection medicine that stop the infection fast. You dont need health insurance to treat a yeast infection onlineplus well send you over the counter yeast infection meds to prevent reocurrence.
Pain when you pee
Red, swollen or sore vaginal tissues
Itching and soreness around the vaginal opening
Discharge that is watery, white & clumpy
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Who Shouldnt Take Diflucan
Pregnant women are advised not to take Diflucan.
The Centers for Disease Control and Prevention recommends that pregnant women and potentially pregnant women only use topical antifungal medications for treating vulvovaginal yeast infections.
Individuals with liver problems are also advised to avoid Diflucan.
Continuing to take Diflucan despite existing liver issues and excessive alcohol drinking can result in liver failure.
The case can potentially be severe enough to need a liver transplant.
Anyone with existing heart conditions may also need to refrain from taking Diflucan since the medication may increase the risk of arrhythmia or heart rhythm problems.
People allergic to fluconazole and other azole antifungal drugs are also advised not to take Diflucan.
Insisting on taking Diflucan may result in difficulty breathing and life-threatening anaphylaxis.
What Other Information Should I Know
Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your response to fluconazole.
Do not let anyone else use your medication. Ask your pharmacist if you have questions about refilling your prescription. If you still have symptoms of infection after you finish taking the fluconazole, call your doctor.
It is important for you to keep a written list of all of the prescription and nonprescription medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
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Urinary Infections Due To Candida Spp
Candida is by far the most frequent agent of urinary fungal infections. The line between colonization and real infection is generally blurred. Candiduria usually present as nosocomial infections, favoured by indwelling urinary catheters, immunosuppressive drugs or antibiotic prescriptions, diabetes mellitus and extreme ages. C. albicans is involved in half of the cases, followed by C. glabrata in 15% of the cases. In 10% of cases, infection involves more than one species. Fluconazole achieves a 10 times higher concentration in urine than in blood with powerful effect even on C. glabrata infections. Therefore, it represents a first line treatment of any Candida urinary tract infection.
In a randomized placebo-controlled multicentre study among patients with asymptomatic candiduria, Sobel et al. found that fluconazole hastened the time to negative results of urine cultures. However, the rate of negative urine cultures 2 weeks after the end of therapy was similar in the fluconazole- and placebo-treated groups, showing the minimal utility of treatment in that setting. Indeed, asymptomatic candiduria should be treated only in high-risk situations, namely patients with neutropenia, infants with low birth weight, patients with renal allografts, and patients who will undergo urologic manipulations . The optimal regimen in that setting is not known. Short courses regimen are not recommended and therapy for 12 weeks should be efficient.
- Typical dosage: One 150-mg dose.
In Patients Receiving A Single Dose For Vaginal Candidiasis
During comparative clinical studies conducted in the United States, 448 patients with vaginal candidiasis were treated with Diflucan, 150 mg single dose. The overall incidence of side effects possibly related to Diflucan was 26%. In 422 patients receiving active comparative agents, the incidence was 16%. The most common treatment-related adverse events reported in the patients who received 150 mg single dose fluconazole for vaginitis were headache , nausea , and abdominal pain . Other side effects reported with an incidence equal to or greater than 1% included diarrhea , dyspepsia , dizziness , and taste perversion . Most of the reported side effects were mild to moderate in severity. Rarely, angioedema and anaphylactic reaction have been reported in marketing experience.
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Carcinogenesis Mutagenesis And Impairment Of Fertility
Fluconazole showed no evidence of carcinogenic potential in mice and rats treated orally for 24 months at doses of 2.5 mg/kg/day, 5 mg/kg/day, or 10 mg/kg/day . Male rats treated with 5 mg/kg/day and 10 mg/kg/day had an increased incidence of hepatocellular adenomas.
Fluconazole, with or without metabolic activation, was negative in tests for mutagenicity in four strains of S. typhimurium, and in the mouse lymphoma L5178Y system. Cytogenetic studies in vivo andin vitro showed no evidence of chromosomal mutations.
Fluconazole did not affect the fertility of male or female rats treated orally with daily doses of 5 mg/kg, 10 mg/kg, or 20 mg/kg or with parenteral doses of 5 mg/kg, 25 mg/kg, or 75 mg/kg, although the onset of parturition was slightly delayed at 20 mg/kg PO. In an intravenous perinatal study in rats at 5 mg/kg, 20 mg/kg, and 40 mg/kg, dystocia and prolongation of parturition were observed in a few dams at 20 mg/kg and 40 mg/kg, but not at 5 mg/kg. The disturbances in parturition were reflected by a slight increase in the number of still born pups and decrease of neonatal survival at these dose levels. The effects on parturition in rats are consistent with the species specific estrogen-lowering property produced by high doses of fluconazole. Such a hormone change has not been observed in women treated with fluconazole.
Medication For Treating Yeast Infections
Standard medicines for yeast infections are all a part of the class of antifungal drugs called azoles. They include:
Treatments last one, three, or seven days, all of which are equally effective. Unless you have an allergic reaction to the medication, side effects are generally mild.
You should not use tampons while using the suppositories and creams. You should also avoid condoms and diaphragms because the medicines contain oil, which can degrade the contraceptives.
Having sex while being treated for a yeast infection is not generally recommended because it may worsen symptoms and cause micro-tears in your skin that increase your risk of catching a sexually transmitted disease.
Diflucan is a prescription pill for yeast infections. Most women only require a single dose of the medication to clear their yeast infection, but fluconazole is not recommended for pregnant women due to a potential risk of harming the developing baby.
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Fluconazole Dosage For Cryptococcal Meningitis
Cryptococcal meningitis is diagnosed by obtaining a culture of the cerebral spinal fluid via a lumbar puncture. In non-HIV infected patients, fluconazole is not typically used for the beginning phase of therapy . Rather, amphotericin B and flucytosine are the antifungals of choice. As alternative options, fluconazole 800 mg plus amphotericin B for two weeks may be used for some patients for induction therapy. This may be followed by consolidation therapy with fluconazole 400 to 800 mg daily for eight weeks, followed by maintenance therapy with fluconazole 200 to 400 mg daily for six to 12 months.
Another alternative option is fluconazole 1200 mg daily by itself for at least 10 weeks for induction therapy, followed by fluconazole 200 to 400 mg daily as maintenance therapy.
When To Call Your Doctor
Reach out to your doctor or pharmacist if you have any questions about your prescription and how to take your medicine. Check in with your doctors office if your symptoms dont disappear after you finish taking all your medicine as prescribed.
See your doctor if you have four or more vaginal yeast infections in one year. It could be a condition called ârecurrent vulvovaginal candidiasis.â Itâs not common, but if you have it, you may need to take an antifungal medication for up to 6 months.
Frequent, repeated yeast infections can also be a sign of a resistant strain or more serious condition, including untreated diabetes. Your doctor can help you figure out what the problem is.
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