Vitamin B12 And Hyperhomocysteinemia
Vitamin B12 deficiency is a much more common cause of hyperhomocysteinemia in developed countries than folate deficiency because of widespread fortification of food with folate. Although epidemiologic studies have shown an association between vascular disease and hyperhomocysteinemia, large randomized controlled trials have shown that lowering homocysteine levels in these patients does not reduce the number of myocardial infarctions or strokes, or improve mortality rates.32 Similarly, an association between elevated homocysteine levels and cognitive impairment has been noted, but subsequent vitamin B12 replacement does not have preventive or therapeutic benefit.33
Data Sources: A PubMed search was completed in Clinical Queries using the key terms vitamin B12, cobalamin, deficiency, and treatment. The search included meta-analyses, randomized controlled trials, clinical trials, and reviews. Also searched were the Agency for Healthcare Research and Quality evidence reports, Clinical Evidence, the Cochrane database, Essential Evidence, the Institute for Clinical Systems Improvement, the National Guideline Clearinghouse database, and the U.S. Preventive Services Task Force. Search dates: March 1, 2016 October 20, 2016 and June 9, 2017.
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Typical Dosing For Vitamin B12
- Oral: Vitamin B12 liquid and tablets are available in various forms and dosages. A typical oral dose is about 1000 mcg daily.
- Nasal spray: Start with one spray in one nostril once weekly. Your provider may adjust your dose after checking your labwork.
- Injection: The typical dose is 100 mcg. Depending on your medical condition, you may need to start by taking it every day, then less frequently as your condition improves. Your provider will adjust your dose after checking your labwork. If you have pernicious anemia, you’ll need to inject 100 mcg monthly.
Some Side Effects Can Be Serious If You Experience Any Of These Symptoms Call Your Doctor Immediately:
- bloody, or watery stools, stomach cramps, or fever during treatment or for up to two or more months after stopping treatment
- stomach tenderness, pain or bloating
- nausea and vomiting
- severe pain in the side and back below the ribs
- painful urination
- urinating more often than usual
- pink, brown, red, cloudy, or bad smelling urine
- swelling in legs and feet
- a return of fever, sore throat, chills, or other signs of infection
- peeling, blistering, or shedding skin
- difficulty swallowing or breathing
- swelling of the throat or tongue
Ceftriaxone injection may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
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Increases Energy Levels And Concentration
If you are constantly lethargic even after a full night of sleep, you may have need B12 shots. This vitamin is required in the production of red blood cells. Red blood cells transport oxygen around your body, providing the fuel your cells need to produce energy. A loss of red blood cell production will create symptoms of low energy and inability to concentrate.
How Should This Medicine Be Used
Ceftriaxone injection comes as a powder to be mixed with liquid, or as a premixed product, to be injected intravenously over a period of 30 or 60 minutes.Ceftriaxone injection can also be given intramuscularly . It is sometimes given as a single dose and sometimes given once or twice a day for 4-14 days, depending on the type of infection being treated.
You may receive ceftriaxone injection in a hospital or doctor’s office, or you may administer the medication at home. If you will be receiving ceftriaxone injection at home, your healthcare provider will show you how to use the medication. Be sure that you understand these directions, and ask your healthcare provider if you have any questions.
You should begin to feel better during the first few days of your treatment with ceftriaxone injection. If your symptoms do not improve or get worse, call your doctor.
If you will be using more than one dose of ceftriaxone injection, use the medication until you finish the prescription, even if you feel better. If you stop using ceftriaxone injection too soon or skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics.
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Sinus Cocktail Shots Q& a
A sinus cocktail shot is a treatment to reduce the symptoms of a common cold or a cold that turns into sinusitis.
The common cold is caused by a virus that gets into your nose and throat and causes an infection. Everyone who has ever had a cold recognizes the symptoms:
- Runny nose
The common cold usually runs its course in 7-10 days.
Your sinuses are lined by tissues that produce mucus. Normally the mucus leaves the sinus through a small opening and runs into your nose.
The virus that causes the common cold can easily travel from your nose and throat into your sinuses. When that happens, the lining becomes inflamed and blocks the opening. Then the mucus gets trapped inside and an infection develops. Thats when you have sinusitis.
Though not as common, sinusitis could occur due to a bacterial infection. Or you might develop a bacterial infection in the trapped mucus after the virus clears up.
Neural Tube Defects And Folic Acid
As with a vitamin B12 deficiency, a lack of folate can also affect an unborn baby’s growth and development in the womb .
This increases the risk of neural tube defects, such as spina bifida, developing in the unborn baby.
It’s recommended that all women who could get pregnant should take a daily supplement of folic acid.
You should take a 400 microgram supplement of folic acid every day before you get pregnant, and up until you’re 12 weeks pregnant.
Page last reviewed: 23 May 2019 Next review due: 23 May 2022
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Vegan Diet And Vitamin B12 Deficiency
Does following a vegan diet leave you with vitamin B12 deficiency symptoms? Its something to consider, experts say. After all, fish, meat, poultry, eggs, and dairy productsall foods not included in a vegan dietare classic sources of vitamin B12. So its a good idea to have your B12 levels checked when you have your annual blood work done. Very low levels may suggest you need monthly or bi-weekly B12 injections to restore and maintain healthy levels.
Vitamin B12 is essential for healthy functioning of your brain, nervous system, and metabolism. Vitamin B12 deficiency symptoms may include:
- Fatigue and muscle weakness and even such alarming symptoms as heart palpitations and shortness of breath
- Nerve problems such as numbness and tingling, especially in your hands and feet. These symptoms may even affect your ability to walk properly
- Changes in the way your tongue looks. It may become smoother but swollen
- Changes in your skins appearance it may become pale or jaundiced
- Emotions and your thinking. People with low B12 levels often complain of memory problems and depressive symptoms. If left untreated, B12 deficiency can lead to serious brain issues and other neurological problems.
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Lipo Dissolving Injection Ppc
Lipodissolve or mesotherapy involves a series of injections of medications that are purported to melt away localized fat deposits. The drugs most regularly used in are phosphatidylcholine and deoxycholate
Localized injections of phosphatidylcholine with deoxycholate to reduce superficial deposits of fat have gained popularity. Initially, different practitioners added multiple other ingredients, including L-carnitine, aminophylline, collagenase, various vasodilators, and hyaluronidase. A standard formula with PC and DC as essential ingredients.
- Supports Lipolysis by decreasing the size of fat cells
- Indirectly increases the local metabolism and blood flow
- Enhances the skin elasticity & skin tone
- Suitable for post liposuction and lymphatic drainage treatments
- Suitable for post pregnancy care
1.5mm reduction in fat layer, Remarkable increase in skin elasticity.
The chart on the left shows fat loss in mm. The chart on the right shows skin elasticity. Study conducted on the thigh area of 10 women ages between 21 and 44.
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Other Uses For This Medicine
Ceftriaxone injection is also sometimes used to treat sinus infections, endocarditis , chancroid , Lyme disease , relapsing fever , shigella , typhoid fever , salmonella , and Whipple’s disease . Ceftriaxone injection is also sometimes used to prevent infection in certain penicillin-allergic patients who have a heart condition and are having a dental or upper respiratory tract procedure, patients who have fever and are at high risk for infection because they have very few white blood cells, close contacts of someone who is sick with meningitis, and in people who have been sexually assaulted or who have been bitten by humans or animals. Talk to your doctor about the risks of using this medication for your condition.
This medication may be prescribed for other uses ask your doctor or pharmacist for more information.
Why Vitamin B12 Is Important
The human body needs vitamin B12 to make red blood cells, nerves, DNA, and carry out other functions. The average adult should get 2.4 micrograms a day. Like most vitamins, B12cant be made by the body. Instead, it must be gotten from food or supplements.
And therein lies the problem: Some people dont consume enough vitamin B12 to meet their needs, while others cant absorb enough, no matter how much they take in. As a result, vitamin B12 deficiency is relatively common, especially among older people.
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Risk Factors For B12 Deficiency
Risk factors for vitamin B12 deficiency include:
- Being over age 50 because you may produce less stomach acid and have trouble absorbing B12 from your diet
- Having a disease called pernicious anemia, which decreases stomach acid and B12 absorption
- Being a vegetarian, because B12 is not found in plant foods
- Having a digestive system disease or surgery that interferes with your abiotic to absorb B12
What Are The Side Effects Of Vitamin B12
With any medication, there are risks and benefits. Even if the medication is working, you may experience some unwanted side effects.
Contact your doctor immediately if you experience any of the following:
- Severe allergic reaction
- Eye nerve damage
- Low potassium levels and/or high platelet counts
The following side effects may get better over time as your body gets used to the medication. Let your doctor know immediately if you continue to experience these symptoms or if they worsen over time.
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What Are The Benefits
Corticosteroids work to reduce inflammation and swelling in your sinuses. This makes it easier for nasal mucus to drain into your stomach like it usually does. It also reduces pressure in your sinuses, which helps to minimize pain associated with sinus infections.
Steroid injections administer steroids directly into inflamed tissue. This method is much more direct than using a nasal spray or taking an oral steroid.
However, frequent steroid injections can lead to health problems, so theyre usually only used for severe or long-lasting sinus infections.
Vitamin B12 Deficiency Symptoms
Vitamin B12 deficiency can be slow to develop, causing symptoms to appear gradually and intensify over time. It can also come on relatively quickly. Given the array of symptoms a vitamin B12 deficiency can cause, the condition can be overlooked or confused with something else. Vitamin B12deficiency symptoms may include:
- strange sensations, numbness, or tingling in the hands, legs, or feet
- difficulty walking
- difficulty thinking and reasoning , or memory loss
While an experienced physician may notice the symptoms and be able to detect a vitamin B12 deficiency with a good interview and physical exam, a blood test is needed to confirm the condition.
Its a good idea to ask your doctor about having your B12 level checked if you are a strict vegetarian or have had weight-loss surgery or have a condition that interferes with the absorption of food.
Early detection and treatment is important. If left untreated, the deficiency can cause severe neurologic problems and blood diseases.
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Primary Care Practice Located In Southaven Ms
When a cold makes you feel miserable or, worse, your cold turns into a sinus infection, it may be time to consider sinus cocktail shots. At Desoto Family Care Clinic, Diosan Powell, FNP, Cynthia Burchfield, FNP, and Danielle Bradley, FNP, combine several medications into a shot that may relieve your symptoms and reduce sinus inflammation. To learn if a sinus cocktail shot could help you feel better, call the office in Southaven, Mississippi, or book an appointment online.
- Request Appointment
Tenderness Of The Face
One of the symptoms doctors will look for when diagnosing a sinus infection is tenderness of the face. When you have this illness, the sinuses become inflamed or infected and fluid can build up in these air-filled spaces. This build up is to blame for many symptoms, such as increased pressure that causes facial pain.
You have sinuses between the eyes, as well as behind the forehead, nose, and cheeks. The pressure can cause pain to occur in any of these areas and is a big reason why you might develop a headache during a sinus infection.
BlurryMe / Shutterstock
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It Can Be Hard To Recognize A Deficiency
“Because the body can store B12 for three to five years, early symptoms of a deficiency usually appear gradually, so you’re unlikely to notice them,” says Middleberg. After initial clues like fatigue, weakness, and brain fog set in, says Middleberg, more advanced tip-offs show up, such as numbness and tingling of the limbs, depression, and paranoia, even hallucinations. The signs are so varied and they don’t strike everyone, so it’s tough to diagnose even at a later stage. “Which symptoms hit when depends also on what caused the deficiencymalabsorption, which could mean they are absorbing some B12 and the deficiency is occurring more slowly, or total lack of animal products, which would likely cause the deficiency to develop more quickly,” says Middleberg.
Researchers Show Chronic Sinusitis Is Immune Disorder Antifungal Medicine Effective Treatment
- University At Buffalo
- Researchers at the University at Buffalo and the Mayo Clinic have shown that chronic sinusitis is an immune disorder caused by fungus, opening up a promising new avenue for treating this ubiquitous and debilitating condition, for which there is no FDA-approved therapy.
BUFFALO, N.Y. — Researchers at the University at Buffalo and the Mayo Clinic have shown that chronic sinusitis is an immune disorder caused by fungus, opening up a promising new avenue for treating this ubiquitous and debilitating condition, for which there is no FDA-approved therapy.
Results of their research suggest that common airborne fungi lodge in the mucus lining of the sinuses in most people, but initiate an immune response only in individuals prone to chronic sinusitis. The immune response causes the fungi to be attacked, which leads to damage of the sinus membranes, resulting in full-blown symptoms.
“We hope this study will lead to the first treatment aimed at the root cause of chronic sinusitis, rather than a treatment just to mask the symptoms,” said David A. Sherris, M.D., interim chair of the UB Department of Otolaryngology.
Sherris presented the study findings today at the annual meeting of the American Academy of Allergy, Asthma and Immunology in San Francisco. The research was conducted while Sherris was at the Mayo Clinic.
The research was supported by grants from the National Institutes of Health and the Mayo Foundation for Education and Research.
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I Know What It Is Now What
Once you understand the checklist youll have a much better idea of which category you fall into. Of course, youll want to confirm this with your doctor for an official diagnosis. If you think that you are one of the majority and that your sinus headaches are actually migraine then its time to see a headache specialist. The good news is that with good treatment and support from a specialist you can significantly improve your condition.
Many people with headaches and sinus complaints self-treat with over the counter medications like ibuprofen or acetaminophen/paracetamol. In most cases, migraine-specific medication and personalized strategies are far more effective.
A range of treatment options are available depending on the severity and frequency of your headaches.
One of the most effective types of medicinal migraine treatments are called the triptans. Ninety-two percent of people from the SAMS study were candidates for triptans, but only 12% were using them.
Triptans require a doctors prescription and can be very useful if headaches are not very frequent. For more severe and frequently recurring cases there are preventative treatment options which help prevent attacks before they occur. There are medicinal and non medicinal preventives which you should explore with your doctor.
A word of caution: migraine overall is poorly managed.
Many people still havent been diagnosed. Fewer receive quality treatment.
IF YOU HAVE MIGRAINE DO THIS NEXT BEFORE THINGS GET WORSE
It’s Hard To Overdo Vitamin B12
Unlike fat-soluble vitamins that accumulate in your body and can have side effects in excess, B12 is a water-soluble vitamin, meaning your body only absorbs a small amount and the rest is excreted through urine, says Middleberg. That’s good news if you need to refill your stores of this nutrient but worry about taking too much. But keep in mind that large amounts of B12 at one time may cause diarrhea and all-over itchiness, she adds. If your doctor recommends supplements, read the label and take only the amount recommended by your MD.
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What Is Vitamin B12 Deficiency
Dr. Alabbas specializes in treating patients with low levels of vitamin B12 in their bodies. If you arent getting enough vitamin B12, you run the risk of experiencing any of the following symptoms:
In some cases, vitamin B12 deficiency can lead to nerve damage and cause numbness and tingling in the hands and feet. Children are also susceptible to vitamin B12 deficiency. In children, deficiency can lead to developmental issues.