How Should I Use This Medicine
This medicine is for external use only. Do not take by mouth. Follow the directions on the prescription label. Wash your hands before and after use. Apply this medicine with each diaper change. Gently cleanse the diaper area with mild soap and warm water. Pat the area dry with a soft towel. Apply a thin layer of medicine to the diaper area. Do not rub this medicine into the skin. Rubbing the skin can cause irritation. Finish the full course prescribed by your doctor or health care professional even if you think your condition is better. Do not stop using except on the advice of your doctor or health care professional.
Talk to your pediatrician regarding the use of this medicine in children. This medicine is not approved for use in children under 4 weeks old.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
What Should I Discuss With My Healthcare Provider Before Using Zinc Oxide Topical
You should not use this medicine if you are allergic to zinc, dimethicone, lanolin, cod liver oil, petroleum jelly, parabens, mineral oil, or wax.
Zinc oxide topical will not treat a bacterial or fungal infection. Call your doctor if you have any signs of infection such as redness and warmth or oozing skin lesions.
Ask a doctor before using this medicine if you are pregnant or breastfeeding.
Are There Any Other Precautions Or Warnings For This Medication
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
External use: This medication is for external use only. If it comes into contact with eyes, thoroughly rinse them with water.
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Protects Skin From Sun Damage
Researchers have found that zinc has natural sun-protection benefits. When your skin is filled with a rich layer of zinc oxide, it reflects and absorbs the UVA and UVB rays . This way it blocks the harmful rays from entering your skin. However, the efficacy of this ingredient completely depends on its concentration.
Different products use different percentages of zinc oxide which is why the effect varies. The more zinc oxide is on your skin, the longer it is protected from sun damage. Usually, sunscreens contain 25% to 30% of zinc oxide.
Determination Of Synergy Between Antifungal Agents By The Fractional Inhibitory Concentration Index In A Checkerboard Assay
The synergy between ZnO QDs and antifungal drugs was determined by calculating the fractional inhibitory concentration index in a checkerboard assay. The individual potency of four different combinations comprising of ZnO QDs and antifungal drugs , where each was used at very low concentrations, was assessed by comparing with their individual activities against isogenic matched pairs of C. albicans strains .
FIC index was determined by a two-dimensional broth microdilution checkerboard assay, as described in the Clinical Microbiology Procedures Handbook . The assay was performed in 96-microtiter plates, where YEPD media was added aseptically in all wells and the concentration range was between 0.178200 µg/ml for ZnO QDs, 0.12564 µg/ml for fluconazole, and 0.0158 µg/ml each for ketoconazole, amphotericin B, and nystatin. In each plate, the antifungal drug was serially diluted along the abscissa, while ZnO QDs were serially diluted along the ordinate. Subsequently, inoculum of 104 CFU/ml of each Candida strain was prepared separately in YEPD media. Then, 100 µl of the respective cell suspension was added into each well of the 96-well plates containing test compounds and incubated for 48 h at 30°C. The MICs of each antifungal drug alone, ZnO QDs alone, and their combinations were determined both visually and by measuring the ODs of cells at 600 nm using a microtiter plate reader. The inhibition in growth of fungal cells was calculated with respect to the growth control .
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Where Should I Keep My Medicine
Keep out of the reach of children.
Store at room temperature between 15 and 30 degrees C . Throw away any unused medicine after the expiration date.
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.
Does Zinc Oxide Work For Eczema
Zinc is present throughout your body, but especially in your bones, muscles, liver, and skin.
During an eczema flare-up, the body releases histamine, which causes you to feel itchy. You may also see small blisters or flaky, cracked, dry skin. Zinc can help address these weak points created in the skin during a flare-up.
Creams with zinc provide a moisture barrier to help soothe the dry, flaky skin that is common with eczema. Zinc creams can also help fight possible infections because of the mineral’s natural antibacterial properties and ability to promote healing.
Zinc oxide may even help with itching by inhibiting the release of histamine.
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Zinc Homeostasis And Viral Infection
Systemic and intracellular zinc are tightly regulated, such that free zinc ions represent a minimal fraction of total cellular zinc . The vast majority of zinc remains bound to zinc-binding proteins such as serum albumin or intracellular metallothionein proteins, where it can be transferred to zinc-binding enzymes and transcription factors as necessary. Zinc transport is principally mediated by 2 groups of proteins: the ZnT family, which is responsible for efflux of zinc outside the cell or influx into organelles, and the ZIP family of proteins, which performs the opposite role, transporting zinc into the cytoplasm from extracellular sources or cellular organelles . The > 30 human proteins responsible for zinc homeostasis collectively ensure that zinc does not become toxic in the case of dietary excess, nor limited in the case of dietary insufficiency. Of course, this balance cannot be maintained indefinitely, and may result in zinc-induced copper deficiency if consumed in excess , and severe zinc deficiency if it is lacking in the diet .
Metallothioneins, zinc homeostasis, and antiviral activity
Is Zinc Oxide Safe For Your Skin
Usually, zinc oxide is a safe ingredient used in cosmetics. It is used in several over-the-counter skin protectants and sunscreen drug products. However, it is best to conduct a patch test on your skin before using any of such skin care products. When used to treat wounds or other skin conditions, do consult your doctor first.
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Is A Yeast Infection From Diaper Rash Contagious
Candida infections are the major cause of diaper rash in children. Most commonly, yeast can cause infection of skin and mucous membranes. Such infections are called mucocutaneous candidiasis, which occur mainly in warm, moist areas of the body where the skin is often folded together, for example,
- diaper rash in infants, babies, toddlers, and children.
Candida infection also can infect
How Should I Use Miconazole And Zinc Oxide Topical
Use exactly as directed on the label, or as prescribed by your doctor.
Your doctor may perform lab tests to make sure you have the type of infection that this medicine can treat effectively.
Read and carefully follow any Instructions for Use provided with your medicine. Ask your doctor or pharmacist if you do not understand these instructions.
Clean and dry the affected area before applying this medicine. You may use a mild soap.
Use the ointment for 1 week, each time you change a diaper. This medicine will not be effective without frequent diaper changes.
Change your child’s diapers as soon as they become wet or soiled. Keep the diaper area clean and dry.
Do not use miconazole and zinc oxide topical to prevent diaper rash or you may increase your child’s risk of infection that is resistant to treatment. Miconazole and zinc oxide topical ointment is not for use on general diaper rash without a related yeast infection.
Allow the spray to dry completely before you dress. There is no need to rub in the medicine.
Use this medicine for the full prescribed length of time, even if your symptoms quickly improve. Skipping doses can increase your risk of infection that is resistant to medication.
Do not share this medicine with another person, even if they have the same symptoms you have.
Store at room temperature away from moisture and heat. Keep the tube or bottle tightly capped when not in use.
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How Zinc Starves Lethal Bacteria To Stop Infection
- University of Adelaide
- Researchers have found that zinc can starve one of the worlds most deadly bacteria by preventing its uptake of an essential metal.
Australian researchers have found that zinc can ‘starve’ one of the world’s most deadly bacteria by preventing its uptake of an essential metal.
The finding, by infectious disease researchers at the University of Adelaide and The University of Queensland, opens the way for further work to design antibacterial agents in the fight against Streptococcus pneumoniae.
Streptococcus pneumoniae is responsible for more than one million deaths a year, killing children, the elderly and other vulnerable people by causing pneumonia, meningitis, and other serious infectious diseases.
Published today in the journal Nature Chemical Biology, the researchers describe how zinc “jams shut” a protein transporter in the bacteria so that it cannot take up manganese, an essential metal that Streptococcus pneumoniae needs to be able to invade and cause disease in humans.
“It’s long been known that zinc plays an important role in the body’s ability to protect against bacterial infection, but this is the first time anyone has been able to show how zinc actually blocks an essential pathway causing the bacteria to starve,” says project leader Dr Christopher McDevitt, Research Fellow in the University of Adelaide’s Research Centre for Infectious Diseases.
Physicochemical Characterization Of Zinc Oxide Quantum Dots
Figure 1A shows the typical absorption peak of ZnO QDs at 365 nm , indicating the formation of ZnO QDs. Figure 1B represents the X-ray diffraction peaks at 31.89°, 35.45°, 36.46°, 47.82°, 56.77°, 62.90°, and 68.40°. XRD confirmed a single phase hexagonal wurtzite structure, which was in agreement with JCPDS , file no. 361,451. Furthermore, the TEM image revealed the average size of ZnO QDs to be 46 nm , while HRTEM confirmed the d spacing as 0.201 nm between the atomic planes of ZnO QDs , which was in accordance with XRD data. The corresponding selected area electron diffraction pattern confirmed the crystalline nature of ZnO QDs and the obtained rings matched with the diffraction planes of the XRD spectra . TEM-EDX mapping revealed the presence of only zinc and oxygen elements in ZnO QDs , while EDX spectra displayed typical sharp peaks of zinc around 1 and 8.6 keV and a single peak of oxygen at 0.5 keV, indicating no trace of impurity in the sample .
FIGURE 1. Absorbance spectrum of ZnO QDs and absorbance maxima observed at 365 nm X-ray diffraction of ZnO QDs.
FIGURE 2. TEM image showing spherical ZnO QDs histogram depicting mean size of ZnO QDs high-resolution TEM image of ZnO QDs, where lattice spacing d= 0.201 nm selected area electron diffraction pattern of ZnO QDs TEM-EDX mapping of ZnO QDs TEM-EDX spectra of ZnO QDs with strong peaks at 0.5, 1.0, and 8.6 keV.
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Zinc Oxide Benefits For Protecting Your Skin From The Sun + More
For more than 2,000 years, weve turned to zinc to help deal with burns and wounds. Today, zinc oxide benefits are even more broad, but looking back , records show that zinc itself was first used in natural healing skin salve called pushpanjan. This was first described in ancient Indian medicinal scripts around the year 500 B.C.
Today, zinc oxide is a key active ingredient in many diaper rash creams, calamine lotions, mineral sunscreens , vitamin supplements and acne treatments sold in drug stores or prescribed by doctors.
Fractional Inhibitory Concentration Index
TABLE 2. MIC values of antifungal drugs against C. albicans strains.
TABLE 3. FIC index for different combinations of ZnO QDs and antifungal drugs tested against C. albicans strains.
FIGURE 4. | Percentage of growth inhibition in C. albicans strains in the presence of both drugs and ZnO QDs as compared to growth control : Fluconazole + ZnO QDs Ketoconazole + ZnO QDs Amphotericin B + ZnO QDs Nystatin + ZnO QDs. The values are mean ± SD of three independent sets of experiments. **** represents p< 0.0001, *** represents p< 0.0002, ** represents p< 0.0046, * represents p< 0.0408, calculated with respect to growth control.
Synergism observed in combinations indicates that ZnO QDs and individual drugs probably share a non-competitive cellular target, which potentiates the antifungal activity against both drug-susceptible and resistant strains, even at concentrations much lower than their respective individual MICs. However, the FIC index for the checkerboard assay has certain limitations since it only tests antimicrobials for a fixed incubation time rather than a continuous time frame and is also not capable of testing more than two antimicrobials at a time , which can slow down the assessment of potential synergistic combinations appropriately . Therefore, spot assay was further performed in this study to validate the results.
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What Is The Difference Between A Yeast Infection And Diaper Rash
Diaper rash lasting about 3 or more days may be caused by Candida in about 45%-75% of all diaper rashes in infants, babies, toddlers, and kids that wear diapers, and is considered Candidal diaper dermatitis or superficial mucocutaneous fungal infection. Consequently, a superficial yeast infection and diaper rash can be the same infection in many infants, babies, toddlers, and children.
In Vitro Cytotoxic Activity Of Zinc Oxide Quantum Dots
The in vitro cytotoxic activity of ZnO QDs was evaluated on HeLa cell line using a trypan blue exclusion assay . Approximately 4 × 104 cells were plated in a culture dish containing DMEM media and allowed to adhere for 12 h, then ZnO QDs were added and incubated for 48 h in a humidified incubator at 37°C. After that, cells were trypsinized, harvested, and resuspended in equal volumes of phosphate buffer saline and 0.4% trypan blue for cell counting. Thereafter, viable and non-viable cells were counted using a hemocytometer to find out the total numbers of living and dead cells after treatment with ZnO QDs.
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In Vitro Cytotoxicity Assay
A colorimetric assay kit was used to measure the cytotoxicity of our materials . Firstly, L929 and HCT-116 cells were cultured in DMEM medium supplemented with 10% FBS at 37 °C in an atmosphere with 5% CO2 and 95% relative humidity. Cells were seeded on 96-well plates at a density of 5×104 cells/well for 24 h to allow cell attachment. The medium was removed and the cells were washed once with PBS. The test materials at certain concentrations in DMEM were added to separate wells in quadruplicate and incubated with the cells for another 24 h. Corresponding samples of DE-ZnO at concentrations of 0.5, 1.0, 1.5, 2.0, 2.5 and 3.0 mg in DMEM were subjected to the same process. After 24 h incubation, the suspensions were removed and the wells were washed once with PBS. A 100 L sample of WST-8 was then added, being careful to not introduce bubbles into the wells, since they interfere with the O.D. reading. Then, the plates were incubated for 4 h at 37 °C in 5% CO2 prior to analysis. We measured the absorbance at 450 nm using a micro-plate reader . Absorbance values for the untreated cells were taken as controls . Cell viability was then calculated according to the following equation:
The biocompatibility of the ZnO nanomaterials and DE were confirmed through cell viability using an MTT assay.
Diaper Rash Or Yeast Infection
If your babys diaper rash lasts for more than a day after youve cleaned and dried the area, and kept her diapers fresh and dry for several changes, she may have a yeast infection.
If the skin is very red and tender in the folds and creases of the diaper area, and the rash lasts more than 3 days, it is almost certainly a yeast infection. You can clear it up quickly by applying zinc oxide cream to the area and changing diapers often. Your pediatrician may prescribe an antifungal cream as well after seeing the rash.
Avoid any cream that contains peanut oil, as these products have been linked to an increase in peanut allergies. If you use cloth diapers, a fabric softener or detergent may be irritating your babys skin.
In any case, its always helpful to let her go diaperless for a while each day. Fresh air can clear up nearly any rash.
As always, be sure to contact your babys doctor if you have any concerns or questions about diaper rash, yeast infection or other health issues.
See also …
- More on diaper rash and yeast infections from the American Academy of Pediatrics
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What Are The Differences In The Causes Of Yeast Infections And Diaper Rash
The main cause of most yeast infections are fungi in the genus Candida. Although this genus causes about 45%-75% of all diaper rashes, some diaper rashes are caused by:
- One percent hydrocortisone cream may reduce discomfort and inflammation.
- There are many over-the-counter antifungal medications, creams and ointments available.
Check with your pediatrician for their recommendations.
Antifungal Assay Via Radial Growth
To determine the effect of the tested nanomaterials on fungi, Aspergillus was used. Dextrose agar culture media for fungi were prepared to perform the antifungal assay. Specific solid medium containing different amounts of the tested nanomaterials were established. Before being used in Petri dishes, the different treatments were mixed to ensure a good dispersion of the tested nanomaterials in the culture medium. We punched a 1 cm diameter hole in the middle of every solidified culture medium. In order to gain homogeneity and reproducibility in the experiment, the fungal spores were collect from the same 15 day old Aspergillus fungi parent. Subsequently, 1000 conidia in 50 L PSB were added to the center hole of each Petri dish containing the culture medium for each of the described treatments. The dishes were move to the culture oven, which was held constant at 25 °C. From the fifth day, a photographic record was taken for each fungi sample. These records were analyzed with Image-J to measure the growth area, and we analyzed the growth rate of each treatment in comparison to the control sample. In addition, the synergy of the nanomaterials with the commercial antibiotics was studied. First of all, we tested the optimized concentration of pure antibiotics, and then 0.5 mg/L amphotericin B and 6.0 g/mL itraconazole were used as the basis for the enhancement study.
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