Are There Any Other Precautions Or Warnings For This Medication
Before you begin using a medication, be sure to inform your doctor of any medical conditions or allergies you may have, any medications you are taking, whether you are pregnant or breast-feeding, and any other significant facts about your health. These factors may affect how you should use this medication.
General: If this is your first yeast infection, if you have frequent yeast infections or heart disease, if you have another yeast infection within 2 months after taking this medication, or if you have multiple sexual partners or change partners often, talk to your doctor or pharmacist before taking this medication. This medication should only be taken as a single dose.
The following symptoms are not caused by a yeast infection. Contact your doctor for treatment advice, if you experience them:
- lower back or shoulder pain
- nausea, vomiting, or diarrhea
- painful urination
If your symptoms have not improved in 3 days or disappeared in 7 days, contact your doctor.
Grapefruit juice: Taking fluconazole at the same time as drinking grapefruit juice may cause fluconazole to build up in the body and cause side effects. Avoid drinking grapefruit juice if you are taking this medication.
Intercourse and birth control: Vaginal intercourse should be avoided when women have a yeast infection. This will help reduce the risk of infecting your sexual partner.
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Dosage In Patients With Impaired Renal Function
Fluconazole is cleared primarily by renal excretion as unchanged drug. There is no need to adjust single dose therapy for vaginal candidiasis because of impaired renal function. In patients with impaired renal function who will receive multiple doses of DIFLUCAN, an initial loading dose of 50 mg to 400 mg should be given. After the loading dose, the daily dose should be based on the following table:
|Hemodialysis||100% after each hemodialysis|
Patients on hemodialysis should receive 100% of the recommended dose after each hemodialysis on non-dialysis days, patients should receive a reduced dose according to their creatinine clearance.
These are suggested dose adjustments based on pharmacokinetics following administration of multiple doses. Further adjustment may be needed depending upon clinical condition.
When serum creatinine is the only measure of renal function available, the following formula should be used to estimate the creatinine clearance in adults:
|72 Ã serum creatinine|
Females: 0.85 Ã above value
Although the pharmacokinetics of fluconazole has not been studied in children with renal insufficiency, dosage reduction in children with renal insufficiency should parallel that recommended for adults. The following formula may be used to estimate creatinine clearance in children:
Can Other Medicines Be Given At The Same Time As Fluconazole
- You can give your child medicines that contain paracetamol or ibuprofen, unless your doctor has told you not to.
- Fluconazole should not be taken with some medicines. Tell your doctor or pharmacist about any other medicines your child is taking before giving Fluconazole.
- Check with your doctor or pharmacist before giving any other medicines to your child. This includes herbal and complementary medicines.
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Dosage And Administration In Adults
The recommended dosage of DIFLUCAN for vaginal candidiasis is 150 mg as a single oral dose.
SINCE ORAL ABSORPTION IS RAPID AND ALMOST COMPLETE, THE DAILY DOSE OF DIFLUCAN IS THE SAME FOR ORAL AND INTRAVENOUS ADMINISTRATION. In general, a loading dose of twice the daily dose is recommended on the first day of therapy to result in plasma concentrations close to steady-state by the second day of therapy.
The daily dose of DIFLUCAN for the treatment of infections other than vaginal candidiasis should be based on the infecting organism and the patient’s response to therapy. Treatment should be continued until clinical parameters or laboratory tests indicate that active fungal infection has subsided. An inadequate period of treatment may lead to recurrence of active infection. Patients with AIDS and cryptococcal meningitis or recurrent oropharyngeal candidiasis usually require maintenance therapy to prevent relapse.
The recommended dosage of DIFLUCAN for oropharyngeal candidiasis is 200 mg on the first day, followed by 100 mg once daily. Clinical evidence of oropharyngeal candidiasis generally resolves within several days, but treatment should be continued for at least 2 weeks to decrease the likelihood of relapse.
Systemic Candida infections
Urinary tract infections and peritonitis
Prophylaxis in patients undergoing bone marrow transplantation
What Other Drugs Could Interact With This Medication
There may be an interaction between fluconazole and any of the following:
If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:
- stop taking one of the medications,
- change one of the medications to another,
- change how you are taking one or both of the medications, or
- leave everything as is.
An interaction between two medications does not always mean that you must stop taking one of them. Speak to your doctor about how any drug interactions are being managed or should be managed.
Medications other than those listed above may interact with this medication. Tell your doctor or prescriber about all prescription, over-the-counter , and herbal medications that you are taking. Also tell them about any supplements you take. Since caffeine, decongestants, alcohol, the nicotine from cigarettes, or street drugs can affect the action of many medications, you should let your prescriber know if you use them.
All material copyright MediResource Inc. 1996 2022. Terms and conditions of use. The contents herein are for informational purposes only. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Source: www.medbroadcast.com/drug/getdrug/Mylan-Fluconazole
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Warnings Of Monistat Vs Diflucan
Women experiencing symptoms of a vaginal yeast infection for the very first time should consult their physician for confirmation of the diagnosis before initiating treatment with any product.
Monistat may interfere with the integrity of latex products and therefore may damage products such as condoms or diaphragms. While using Monistat, you should refrain from using other vaginal products such as tampons, douches, or spermicides. Vaginal intercourse is not recommended while using Monistat products. Monistat products may cause skin sensitivities such as itching, burning, and irritation. If you are pregnant or breastfeeding, you should consult with your doctor before using Monistat.
Diflucan has been associated with rare, but serious, liver damage and should be used with caution in patients with pre-existing hepatic disease. Your doctor may monitor your liver enzymes while on Diflucan, especially if you are on it for an extended duration of treatment. Rare cases of a life-threatening allergic reaction, also known as anaphylaxis, to Diflucan have been reported. Diflucan should be avoided in pregnancy, especially the first trimester.
Diflucan Drug Interactions And Contraindications
Oral Diflucan tablets may interact with other drugs or medications, including vitamins and supplements.
These reactions may affect how well the drug works and cause harm.
Diflucan has relative contraindications with several drugs, including:
Taking Diflucan at the same time as certain medications may not result in serious health complications. Instead, it raises the risk of experiencing side effects associated with the other drug.
Warfarin: Diflucan may increase the likelihood of bruising, nosebleeds, and blood in urine or stools.
Glyburide and Glipizide: Diflucan may increase the risk of low blood sugar, sweating, chills, and fast pulse.
Theophylline: Diflucan may increase the likelihood of side effects like kidney damage.
Methadone and Fentanyl: Diflucan may increase the risk of drowsiness, confusion, and slower breathing.
Zidovudine: Diflucan may raise ones chances of experiencing headaches, appetite loss, nausea, and vomiting.
Vitamin A: According to one case report, taking Diflucan with all-trans-retinoic acid, an acid form of vitamin A, can potentially cause pseudotumor cerebri or false brain tumors.
These are only some of the many drugs that may cause unwanted interactions with Diflucan.
Therefore, disclosing any current medications or treatments during doctors checkups for this infection is always best.
This will help avoid unnecessary and avoidable harmful effects of the drug.
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Dosage And Administration In Children
The following dose equivalency scheme should generally provide equivalent exposure in pediatric and adult patients:
|12* mg/kg||400 mg|
Experience with DIFLUCAN in neonates is limited to pharmacokinetic studies in premature newborns. Based on the prolonged half-life seen in premature newborns , these children, in the first two weeks of life, should receive the same dosage as in older children, but administered every 72 hours. After the first two weeks, these children should be dosed once daily. No information regarding DIFLUCAN pharmacokinetics in full-term newborns is available.
The recommended dosage of DIFLUCAN for oropharyngeal candidiasis in children is 6 mg/kg on the first day, followed by 3 mg/kg once daily. Treatment should be administered for at least 2 weeks to decrease the likelihood of relapse.
For the treatment of esophageal candidiasis, the recommended dosage of DIFLUCAN in children is 6 mg/kg on the first day, followed by 3 mg/kg once daily. Doses up to 12 mg/kg/day may be used, based on medical judgment of the patient’s response to therapy. Patients with esophageal candidiasis should be treated for a minimum of three weeks and for at least 2 weeks following the resolution of symptoms.
Systemic Candida infections
For the treatment of candidemia and disseminated Candida infections, daily doses of 6 to 12 mg/kg/day have been used in an open, noncomparative study of a small number of children.
Drug Interactions Of Monistat Vs Diflucan
Monistat is generally very safe to take with other medications. There is a chance that intravaginal use of miconazole products may result in enough significant systemic absorption to interfere with Coumadin metabolism, causing an increase in plasma levels of warfarin. Therefore, intravaginal use of miconazole in patients taking warfarin is generally not recommended as a precaution.
Diflucan is a strong inhibitor of cytochrome P-450 enzyme subtype CYP2C19, as well as a moderate inhibitor of subtypes CYP2C9 and CYP3A4. This results in a variety of potential drug interactions as these enzymes play important roles in the processing and absorption of many other drugs. Diflucan may interact with blood thinners, antibiotics, oral contraceptives, and other commonly used medications. In addition, Diflucan has been associated with an adverse event known as QT prolongation, a serious irregular heart rhythm. When Diflucan is taken with other drugs that cause QT prolongation, their effects may be potentiated and this effect is potentially fatal. Drugs whose QT prolongation effect may be increased when taken with Diflucan include amiodarone, astemizole, pimozide, quinidine, quetiapine, and erythromycin.
The following table provides a sample of drug interactions, but may not be a complete list. A medical professional can provide additional information and a complete list of interactions.
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Management Of Patients Not Responding To Fluconazole
Emergence of resistance to antifungal drugs does not appear to be a problem during theirshort-term use. Long-term use of fluconazole as prophylaxis and treatment of recurrent oralcandidosis in AIDS patients has, however, led to an increase in the number of reportedfluconazole-resistant cases. In most cases, the term resistance hasbeen used to describe non-responsiveness to conventional doses of fluconazole .Immunocompetent hosts and those with transient immune suppression, owing, for example, tochemotherapy, are only rarely non-responsive to fluconazole.
A number of options are available for managing patients who are non-responsive toconventional doses of fluconazole. Higher doses offluconazole have been tried and found to be successful. In addition, most patients who are non-responsive tofluconazole remain susceptible to wider-spectrum antifungals.
Meningitis Due To Candida Sp
Very few data exist on fluconazoleâs efficacy for the initial treatment of Candida sp. meningitis in adults, although this drug has a very good CSF penetration. Oral fluconazole was successful for the treatment of a C. albicans meningitis in an HIV-infected patient with a CD4 cell count of 35 cells/mm3 who refused intravenous therapy.
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What Other Information Should I Know
Keep all appointments with your doctor and the laboratory. Your doctor may order certain lab tests to check your response to fluconazole.
Do not let anyone else use your medication. Ask your pharmacist if you have questions about refilling your prescription. If you still have symptoms of infection after you finish taking the fluconazole, call your doctor.
It is important for you to keep a written list of all of the prescription and nonprescription medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.
Side Effects Of Diflucan
Like all other medications, Diflucan has its share of side effects and potential adverse reactions.
However, the occurrence and severity of Diflucan side effects depend on the dosage taken.
Diflucans most common side effects are headaches, nausea, and stomach pain. Other common side effects also include:
- Numbness of the hands, feet, or lips
- Increased thirst
Some rare side effects of Diflucan point towards other more serious conditions and adverse effects.
For instance, the combination of dark urine, light-colored stools, severe itching, and vomiting may indicate liver damage.
In addition, muscle weakness, fatigue, appetite loss, and stomach pain are symptoms of adrenal gland problems.
Meanwhile, fast or irregular heart rate, dizziness, fainting, and seizures indicate torsades de pointes, a severe and potentially fatal heart rhythm condition.
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What To Do If Fluconazole Doesnt Work
If you dont see any improvement within 48 hours from taking fluconazole it may be because you yeast infection was caused by a fluconazole-resistant strain, such as Candida glabrata.
Another reason, especially if you self-diagnose, is that youve got a different kind of vaginal infection, such as BV or trichomoniasis.
The good news is that there is a natural over the counter treatment that has been shown to work for difficult to treat yeast infection as well as BV. Its called boric acid.
Boric acid suppositories have got excellent antifungal and antibacterial properties and theyre often used when other treatments fail.
They rarely give any side effects and provide quick results, you can check boric acid suppositories reviews on Amazon.
How Do I Store And/or Throw Out Fluconazole Tablets
- Store at room temperature.
- Store in a dry place. Do not store in a bathroom.
- Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
- Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.
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Prophylaxis Of Candidiasis With Bmt
Prevention of candidiasis incidence in patients undergoing bone marrow transplant
400 mg PO qDay
- Patients who are anticipated to have severe granulocytopenia should start prophylaxis several days before anticipated onset of neutropenia and continue for 7 days after neutrophil count rises > 1000 cells per mm³
Can Fluconazole Cause Problems
Along with their useful effects, most medicines can cause unwanted side-effects although not everyone experiences them. The table below contains some of the most common ones associated with fluconazole. You will find a full list in the manufacturer’s information leaflet supplied with your medicine. The unwanted effects often improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following continue or become troublesome.
|Common fluconazole side-effects||What can I do if I experience this?|
|Feeling sick or being sick , stomach ache, diarrhoea||Stick to simple foods and drink plenty of water|
|Headache||Drink plenty of water and ask your pharmacist to recommend a suitable painkiller. If the headaches continue, let your doctor know|
|Skin rash||Let your doctor know about this|
|Changes to some blood test results||Your doctor will check for these if needed|
If you experience any other symptoms which you think may be due to fluconazole, discuss them with your doctor or pharmacist for further advice.
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Over The Counter Supplements Vs Prescription Medications For Candida
It may be tempting to think or believe that prescription medications are always more powerful than over the counter supplements.
And while this may make sense intuitively, it certainly isnât always the case.
Some studies, such as this, have shown that herbal antibiotics/antifungals can be just as potent than conventional prescription medications.
Having said that, prescription medications certainly have their place, especially when treating gut-related issues such as SIFO and SIBO.
If you prefer the âall-naturalâ approach OR if youâve tried Diflucan/fluconazole without success, there are still many options available to you.
Iâve compiled a list of supplements below that you may want to consider if you have candida:
These supplements can also be combined with prescription medications to increase effectiveness and reduce the risk of fungal resistance.
When I treat patients for fungal overgrowth or candida, I typically use multiple options for that very reason.
Another important point to consider is that killing off candida is only part of the equation to treating your issue.
If you kill off candida but do not fix the issues that caused it to overpopulate in the first place then you will eventually end up where you started.
You will want to ensure that you take the proper precautions such as changing your diet , to reduce your stress , and provide your body with healthy probiotics to take the place of the candida once itâs gone.